NDLI: The Liver-Stage Plasmodium Infection is a Critical Checkpoint for Development of Experimental Cerebral Malaria

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The Liver-Stage Plasmodium Infection is a Critical Checkpoint for Development of Experimental Cerebral Malaria

Content Provider	Scilit
Author	Sato, Yuko Ries, Stefanie Stenzel, Werner Fillatreau, Simon Matuschewski, Kai
Copyright Year	2018
Description	Journal: SSRN Electronic Journal Cerebral malaria is a life-threatening complication in humans, which the pathogenesis is widely analyzed using a murine model of experimental cerebral malaria (ECM). Here, we show abrogation of ECM by sporozoite induced infection of transgenic Plasmodium berghei line overexpressing profilin, while the same parasite is fully virulent in transfusion-mediated blood infection – thus demonstrating the importance of the clinically silent liver-stage infection for the onset of ECM. Infection with transgenic sporozoites did not lead to vascular damages in the brain, even though both parasites triggered comparable cerebral immune cell accumulation. However, infection with the transgenic strain had different systemic activation of Ly6C monocytes and early induction of peripheral cytokines, such as IFN-γ and IL-10. Collectively, our study reveals the essential role of early host interactions in the liver for decisively controlling the subsequent immunity and the occurrence of ECM, highlighting a novel checkpoint in this fatal pathology.
Related Links	https://edoc.hu-berlin.de/bitstream/18452/21531/1/fimmu-10-02554.pdf https://papers.ssrn.com/sol3/Delivery.cfm?abstractid=3299436
ISSN	10914358
e-ISSN	15565068
DOI	10.2139/ssrn.3299436
Journal	SSRN Electronic Journal
Language	English
Publisher	Elsevier BV
Publisher Date	2018-01-01
Access Restriction	Open
Subject Keyword	Journal: SSRN Electronic Journal
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health Psychiatry and Mental Health

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