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Asthma Is a Risk Factor for Respiratory Exacerbations Without Increased Rate of Lung Function Decline
| Content Provider | Scilit |
|---|---|
| Author | Hayden, Lystra P. Hardin, Megan E. Qiu, Weiliang Lynch, David A. Strand, Matthew J. van Beek, Edwin J. Crapo, James D. Silverman, Edwin K. Hersh, Craig P. Make, Barry J. Regan, Elizabeth A. Beaty, Terri Begum, Ferdouse Boueiz, Adel R. Busch, Robert Castaldi, Peter J. Cho, Michael DeMeo, Dawn L. Foreman, Marilyn G. Halper-Stromberg, Eitan Hansel, Nadia N. Hetmanski, Jacqueline Hobbs, Brian D. Hokanson, John E. Laird, Nan Lange, Christoph Lutz, Sharon M. McDonald, Merry-Lynn Parker, Margaret M. Qiao, Dandi Santorico, Stephanie Wan, Emily S. Qaisi, Mustafa Al Coxson, Harvey O. Gray, Teresa Han, Mei Lan K. Hoffman, Eric A. Humphries, Stephen Jacobson, Francine L. Judy, Philip F. Kazerooni, Ella A. Kluiber, Alex Newell, John D. Ross, James C. Estepar, Raul San Jose Schroeder, Joyce Sieren, Jered Stinson, Douglas Stoel, Berend C. Tschirren, Juerg van Ginneken, Bram van Rikxoort, Eva Washko, George Wilson, Carla G. Jensen, Robert Crooks, Jim Everett, Douglas Moore, Camille Strand, Matt Hughes, John Kinney, Gregory Pratte, Katherine Young, Kendra A. |
| Copyright Year | 2017 |
| Description | Journal: Chest Previous investigations in adult smokers from the COPDGene Study have shown that early-life respiratory disease is associated with reduced lung function, COPD, and airway thickening. Using 5-year follow-up data, we assessed disease progression in subjects who had experienced early-life respiratory disease. We hypothesized that there are alternative pathways to reaching reduced $FEV_{1}$ and that subjects who had childhood pneumonia, childhood asthma, or asthma-COPD overlap (ACO) would have less lung function decline than subjects without these conditions. Subjects returning for 5-year follow-up were assessed. Childhood pneumonia was defined by self-reported pneumonia at < 16 years. Childhood asthma was defined as self-reported asthma diagnosed by a health professional at < 16 years. ACO was defined as subjects with COPD who self-reported asthma diagnosed by a health-professional at ≤ 40 years. Smokers with and those without these early-life respiratory diseases were compared on measures of disease progression. Follow-up data from 4,915 subjects were examined, including 407 subjects who had childhood pneumonia, 323 subjects who had childhood asthma, and 242 subjects with ACO. History of childhood asthma or ACO was associated with an increased exacerbation frequency (childhood asthma, P < .001; ACO, P = .006) and odds of severe exacerbations (childhood asthma, OR, 1.41; ACO, OR, 1.42). History of childhood pneumonia was associated with increased exacerbations in subjects with COPD (absolute difference [β], 0.17; P = .04). None of these early-life respiratory diseases were associated with an increased rate of lung function decline or progression on CT scans. Subjects who had early-life asthma are at increased risk of developing COPD and of having more active disease with more frequent and severe respiratory exacerbations without an increased rate of lung function decline over a 5-year period. ClinicalTrials.gov; No. NCT00608764; https://clinicaltrials.gov. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815872/pdf http://journal.chestnet.org/article/S001236921733221X/pdf |
| Ending Page | 377 |
| Page Count | 10 |
| Starting Page | 368 |
| ISSN | 00123692 |
| e-ISSN | 19313543 |
| DOI | 10.1016/j.chest.2017.11.038 |
| Journal | Chest |
| Issue Number | 2 |
| Volume Number | 153 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2017-12-15 |
| Access Restriction | Open |
| Subject Keyword | Journal: Chest Asthma-copd Overlap Childhood Asthma Childhood Pneumonia Respiratory Exacerbations |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Critical Care and Intensive Care Medicine Cardiology and Cardiovascular Medicine |
