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Impacts of maturation on the micromechanics of the meniscus extracellular matrix
| Content Provider | Scilit |
|---|---|
| Author | Li, Qing Wang, Chao Han, Biao Qu, Feini Qi, Hao Li, Christopher Y. Mauck, Robert L. Han, Lin |
| Copyright Year | 2018 |
| Description | Journal: Journal of biomechanics To elucidate how maturation impacts the structure and mechanics of meniscus extracellular matrix (ECM) at the length scale of collagen fibrils and fibers, we tested the micromechanical properties of fetal and adult bovine menisci via atomic force microscopy (AFM)-nanoindentation. For circumferential fibers, we detected significant increase in the effective indentation modulus, $E_{ind}$, with age. Such impact is in agreement with the increase in the fibril diameter and collagen alignment during maturation, and is more pronounced in the outer zone, where collagen fibrils are more aligned and packed. Meanwhile, maturation also markedly increases the $E_{ind}$ of radial tie fibers, but not those of intact surface or superficial layer. These results provide new insights into the effect of maturation on the assembly of meniscus ECM, and enable the design of new meniscus repair strategies by modulating the local ECM structure and mechanical behaviors. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895496/pdf http://www.jbiomech.com/article/S0021929018301519/pdf |
| Ending Page | 257 |
| Page Count | 6 |
| Starting Page | 252 |
| ISSN | 00219290 |
| e-ISSN | 18732380 |
| DOI | 10.1016/j.jbiomech.2018.02.037 |
| Journal | Journal of biomechanics |
| Volume Number | 72 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2018-03-08 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of biomechanics Extracellular Matrix |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Rehabilitation Biophysics Sports Science Biomedical Engineering |
