NDLI: Identification of a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro

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Identification of a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro

Content Provider	Scilit
Author	Miles, Jennifer A. Machattou, Petrina Nevin-Jones, David Webb, Michael E. Millard, Andrew Scanlan, David J. Taylor, Paul C.
Copyright Year	2019
Description	Journal: Biochemical and Biophysical Research Communications Retinoic acid signalling is generally considered to be of animal origin. Recently, retinoic acid has been identified in cyanobacteria, yet no mechanism for its production has been identified. Here, we characterise for the first time a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro. Our computational studies suggest that the cyanobacterial aldehyde dehydrogenase resembles an ancestor of both eukaryotic aldehyde dehydrogenase 1 and aldehyde dehydrogenase 2. The Chlorogloeopsis fritschii aldehyde dehydrogenase described here may find applications in synthetic production of retinoic acid as well as contributing to our understanding of retinoid synthesis in cyanobacteria.
Related Links	http://wrap.warwick.ac.uk/113444/2/WRAP-identification-cyanobacterial-aldehyde-produces-retinoic-Scanlan-2019.pdf
Ending Page	34
Page Count	8
Starting Page	27
ISSN	0006291X
e-ISSN	10902104
DOI	10.1016/j.bbrc.2018.12.171
Journal	Biochemical and Biophysical Research Communications
Issue Number	1
Volume Number	510
Language	English
Publisher	Elsevier BV
Publisher Date	2019-01-17
Access Restriction	Open
Subject Keyword	Journal: Biochemical and Biophysical Research Communications Aldehyde Dehydrogenase Lateral Gene Transfer
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Biochemistry Biophysics

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