NDLI: Dose-dependent white matter damage after brain radiotherapy

Please wait, while we are loading the content...

Dose-dependent white matter damage after brain radiotherapy

Content Provider	Scilit
Author	Connor, Michael Karunamuni, Roshan McDonald, Carrie White, Nathan Pettersson, Niclas Moiseenko, Vitali Seibert, Tyler Marshall, Deborah Cervino, Laura Bartsch, Hauke Kuperman, Joshua Murzin, Vyacheslav Krishnan, Anitha Farid, Nikdokht Dale, Anders Hattangadi-Gluth, Jona
Copyright Year	2016
Description	Journal: Radiotherapy and Oncology Background and purpose Brain radiotherapy is limited in part by damage to white matter, contributing to neurocognitive decline. We utilized diffusion tensor imaging (DTI) with multiple b-values (diffusion weightings) to model the dose-dependency and time course of radiation effects on white matter. Materials and methods Fifteen patients with high-grade gliomas treated with radiotherapy and chemotherapy underwent MRI with DTI prior to radiotherapy, and after months 1, 4–6, and 9–11. Diffusion tensors were calculated using three weightings (high, standard, and low b-values) and maps of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity $$λ\∥$, and radial diffusivity (λ⊥) were generated. The region of interest was all white matter. Results MD,λ\∥, andλ⊥ increased significantly with time and dose, with corresponding decrease in FA. Greater changes were seen at lower b-values, except for FA. Time-dose interactions were highly significant at 4-6months and beyond (p<.001), and the difference in dose response between high and low b-values reached statistical significance at 9-11months for MD,λ\∥, andλ⊥ (p<.001, p<.001, p=.005 respectively) as well as at 4-6months forλ\∥ (p=.04). Conclusions We detected dose-dependent changes across all doses, even <10Gy. Greater changes were observed at low b-values, suggesting prominent extracellular changes possibly due to vascular permeability and neuroinflammation.$
Related Links	https://manuscript.elsevier.com/S0167814016343377/pdf/S0167814016343377.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136508/pdf http://www.thegreenjournal.com/article/S0167814016343377/pdf
Ending Page	216
Page Count	8
Starting Page	209
ISSN	01678140
e-ISSN	18790887
DOI	10.1016/j.radonc.2016.10.003
Journal	Radiotherapy and Oncology
Issue Number	2
Volume Number	121
Language	English
Publisher	Elsevier BV
Publisher Date	2016-11-01
Access Restriction	Open
Subject Keyword	Journal: Radiotherapy and Oncology Radiology, Nuclear Medicine and Imaging Diffusion Tensor Imaging
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Hematology Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in