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Determinants of carotid-femoral pulse wave velocity in prepubertal children
| Content Provider | Scilit |
|---|---|
| Author | Correia-Costa, Ana Correia-Costa, Liane Afonso, Alberto Caldas Schaefer, Franz Guerra, António Moura, Cláudia Mota, Cláudia Barros, Henrique Areias, José Carlos Azevedo, Ana |
| Copyright Year | 2016 |
| Description | Journal: International Journal of Cardiology Pulse wave velocity (PWV) is a noninvasive technique to evaluate arterial stiffness, a dynamic property of the vessels, reflecting their structure and function. Childhood obesity is associated with several cardiovascular comorbidities and to the progression of atherosclerosis. We aimed to compare carotid-femoral PWV between normal weight and overweight/obese prepubertal children and to quantify its association with other cardiovascular risk factors.Cross-sectional study of 315 children aged 8-9years. Anthropometrics, 24-h ambulatory blood pressure (BP) and carotid-femoral PWV were measured. Classification of obesity was according to World Health Organization (WHO) body mass index (BMI)-for-age reference values.Compared to normal weight children, overweight and obese children presented significantly higher levels of PWV (4.95 (P25-P75: 4.61-5.23), 5.00 (4.71-5.33), 5.10 (4.82-5.50) m/s, respectively; ptrend<0.001). Significant positive correlations were found between PWV and total cholesterol, LDL cholesterol, triglycerides, fasting insulin and insulin resistance levels (HOMA-IR) and with high-sensitivity C-reactive protein (hs-CRP). In a multivariate linear regression model adjusted for sex, age, height and 24-h systolic blood pressure z-score, the independent determinants of PWV were BMI, HOMA-IR and the absence of dipping.The association between PWV and the loss of dipping and insulin resistance levels, independently of the BMI, reinforces the contribution of these comorbidities to vascular injury in early life. |
| Related Links | https://repositorio-aberto.up.pt/bitstream/10216/114750/1/CorreiaCostaAL2016.pdf http://www.internationaljournalofcardiology.com/article/S0167527316309688/pdf |
| Ending Page | 42 |
| Page Count | 6 |
| Starting Page | 37 |
| ISSN | 01675273 |
| e-ISSN | 18741754 |
| DOI | 10.1016/j.ijcard.2016.05.060 |
| Journal | International Journal of Cardiology |
| Volume Number | 218 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-05-14 |
| Access Restriction | Open |
| Subject Keyword | Journal: International Journal of Cardiology Peripheral Vascular Disease Pulse Wave Velocity Arterial Stiffness Childhood Obesity Insulin Resistance |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine |
