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Acute Venous Thromboembolism Risk Highest Within 60 Days After Discharge From the Hospital in Patients With Inflammatory Bowel Diseases
| Content Provider | Scilit |
|---|---|
| Author | Faye, Adam S. Wen, Timothy Ananthakrishnan, Ashwin N. Lichtiger, Simon Kaplan, Gilaad G. Friedman, Alexander M. Lawlor, Garrett Wright, Jason D. Attenello, Frank J. Mack, William J. Lebwohl, Benjamin |
| Copyright Year | 2019 |
| Description | Journal: Clinical Gastroenterology and Hepatology Background & Aims Patients with inflammatory bowel diseases (IBDs) have a high risk of venous thromboembolism (VTE). We assessed the timing and risk factors associated with readmission to the hospital for VTE among patients with IBD. Methods We collected data from the Nationwide Readmissions Database on IBD index admissions resulting in readmission to the hospital for VTE within 60 days, from 2010 through 2014. We used univariable and multivariable regression to assess risk factors associated with VTE readmission with unadjusted risk ratio (RR) and adjusted RR (aRR) as measures of effect. Time to VTE readmission was assessed in 10-day intervals, for up to 90 days. Results We identified 872,122 index admissions of patients with IBD; 1160 resulted in readmission with VTE. More than 90% of readmissions occurred within 60 days of discharge from the index admission. Factors associated with hospital readmission with VTE included prior VTE, longer length of hospital stay, comorbidities, having a flexible sigmoidoscopy or colonoscopy at index admission, and age older than 18 years. Additional risk factors included Clostridium difficile infection at index admission (aRR, 1.47; 95% CI, 1.17–1.85) and discharge to a skilled nursing facility or intermediate care facility (aRR, 1.39; 95% CI, 1.14-1.70) or discharge with home health services (aRR, 1.65; 95% CI, 1.41–1.94). Conclusions Among patients admitted to the hospital with IBD, most readmissions with VTE occur within 60 days of discharge. Readmission with VTE is associated with C difficile infection and discharge to a skilled nursing facility, intermediate care facility, or with home health services. Studies are needed to evaluate the potential benefit of extending VTE prophylaxis for patients admitted to the hospital with IBD for up to 2 months after discharge, to minimize risk. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980437/pdf |
| ISSN | 15423565 |
| e-ISSN | 15427714 |
| DOI | 10.1016/j.cgh.2019.07.028 |
| Journal | Clinical Gastroenterology and Hepatology |
| Issue Number | 5 |
| Volume Number | 18 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2020-05-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Clinical Gastroenterology and Hepatology Gastroenterology and Hepatology Nrd, Snf, Ulcerative Colitis Crohn's Disease Pulmonary Embolism |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hepatology Gastroenterology |
