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Dancing Protein Clouds: The Strange Biology and Chaotic Physics of Intrinsically Disordered Proteins
| Content Provider | Scilit |
|---|---|
| Author | Uversky, Vladimir N. |
| Copyright Year | 2016 |
| Description | Journal: Journal of Biological Chemistry Biologically active but floppy proteins represent a new reality of modern protein science. These intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered and intrinsically disordered protein regions (IDPRs) constitute a noticeable part of any given proteome. Functionally, they complement ordered proteins, and their conformational flexibility and structural plasticity allow them to perform impossible tricks and be engaged in biological activities that are inaccessible to well folded proteins with their unique structures. The major goals of this minireview are to show that, despite their simplified amino acid sequences, IDPs/IDPRs are complex entities often resembling chaotic systems, are structurally and functionally heterogeneous, and can be considered an important part of the structure-function continuum. Furthermore, IDPs/IDPRs are everywhere, and are ubiquitously engaged in various interactions characterized by a wide spectrum of binding scenarios and an even wider spectrum of structural and functional outputs. |
| Related Links | http://www.jbc.org/content/291/13/6681.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807255/pdf http://www.jbc.org/article/S0021925820429254/pdf |
| Ending Page | 6688 |
| Page Count | 8 |
| Starting Page | 6681 |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| DOI | 10.1074/jbc.r115.685859 |
| Journal | Journal of Biological Chemistry |
| Issue Number | 13 |
| Volume Number | 291 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-03-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Biological Chemistry Dynamical System Intrinsically Disordered Protein Intrinsically Disordered Proteins Multifunctional Protein Post-translational Modification (ptm) Posttranslational Modification Protein Folding Protein-protein Interaction Structural Heterogeneity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
