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MRI and MRE for non-invasive quantitative assessment of hepatic steatosis and fibrosis in NAFLD and NASH: Clinical trials to clinical practice
| Content Provider | Scilit |
|---|---|
| Author | Dulai, Parambir S. Sirlin, Claude B. Loomba, Rohit |
| Copyright Year | 2016 |
| Description | Journal: Journal of Hepatology Summary Non-alcoholic fatty liver disease (NAFLD) represents one of the most common causes of chronic liver disease, and its prevalence is rising worldwide. The occurrence of non-alcoholic steatohepatitis (NASH) is associated with a substantial increase in disease related morbidity and mortality. Accordingly, there has been a surge of innovation surrounding drug development in an effort to off-set the natural progression and long-term risks of this disease. Disease assessment within clinical trials and clinical practice for NAFLD is currently done with liver biopsies. Liver biopsy-based assessments, however, remain imprecise and are not without cost or risk. This carries significant implications for the feasibility and costs of bringing therapeutic interventions to market. A need therefore arises for reliable and highly accurate surrogate end-points that can be used in phase 2 and 3 clinical trials to reduce trial size requirements and costs, while improving feasibility and ease of implementation in clinical practice. Significant advances have now been made in magnetic resonance technology, and magnetic resonance imaging (MRI) and elastrography (MRE) have been demonstrated to be highly accurate diagnostic tools for the detection of hepatic steatosis and fibrosis. In this review article, we will summarize the currently available evidence regarding the use of MRI and MRE among NAFLD patients, and the evolving role these surrogate biomarkers will play in the rapidly advancing arena of clinical trials in NASH and hepatic fibrosis. Furthermore, we will highlight how these tools can be readily applied to routine clinical practice, where the growing burden of NAFLD will need to be met with enhanced monitoring algorithms. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124376/pdf http://www.journal-of-hepatology.eu/article/S0168827816302677/pdf |
| Ending Page | 1016 |
| Page Count | 11 |
| Starting Page | 1006 |
| ISSN | 01688278 |
| DOI | 10.1016/j.jhep.2016.06.005 |
| Journal | Journal of Hepatology |
| Issue Number | 5 |
| Volume Number | 65 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-06-13 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Hepatology Gastroenterology and Hepatology Magnetic Resonance Imaging Magnetic Resonance Elastography Proton Density Fat Fraction Magnetic Resonance Spectroscopy Non-alcoholic Fatty Liver Disease Non-alcoholic Fatty Liver Non-alcoholic Steatohepatitis Intraclass Correlation Coefficient Standard Deviation Confidence Interval |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hepatology |
