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Interlaced proton grid therapy – Linear energy transfer and relative biological effectiveness distributions
| Content Provider | Scilit |
|---|---|
| Author | Henry, Thomas Ödén, Jakob |
| Copyright Year | 2018 |
| Description | Journal: Physica Medica Interlaced beams have previously been proposed for delivering proton grid therapy. This study aims to assess dose-averaged LET $(LET_{d}$) and RBE-weighted dose $(D_{RBE}$) distributions of such beam geometries, and compare them with conventional intensity modulated proton therapy (IMPT). IMPT plans and four different interlaced proton grid therapy plans were generated for five patient cases (esophagus, lung, liver, prostate, anus). The constant RBE = 1.1 was assumed for optimization. The $LET_{d}$ was subsequently Monte Carlo calculated for each plan and used as input for two LET-dependent variable RBE models. The fulfilment of clinical goals, along with DVH and spatial distribution evaluations, were then assessed and compared. All plans fulfilled the clinical target goals assuming RBE = 1.1. The target coverage was slightly compromised for some grid plans when assuming the variable RBE models. All IMPT plans, and 18 of 20 grid plans, fulfilled all clinical goals for the organs at risk when assuming RBE = 1.1, whereas most plans failed at least one goal when assuming the variable RBE models. Compared with the IMPT plans, the grid plans demonstrated substantially different $LET_{d}$ distributions due to the fundamentally different beam geometries. However, $D_{RBE}$ distributions in the target were similar. Despite the unconventional beam geometries of interlaced proton grid plans, with resulting alternating dose and $LET_{d}$ patterns, the fulfillment of realistic clinical goals seems to be comparable to regular IMPT plans, both assuming RBE = 1.1 and variable RBE models. In addition, the alternating grid patterns do not seem to give rise to unexpected $D_{RBE}$ hot-spots. |
| Related Links | http://www.physicamedica.com/article/S1120179718313115/pdf |
| Ending Page | 89 |
| Page Count | 9 |
| Starting Page | 81 |
| ISSN | 11201797 |
| DOI | 10.1016/j.ejmp.2018.10.025 |
| Journal | Physica Medica |
| Volume Number | 56 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2018-11-22 |
| Access Restriction | Open |
| Subject Keyword | Journal: Physica Medica Radiology, Nuclear Medicine and Imaging Proton Grid Therapy Proton Therapy Relative Biological Effectiveness Linear Energy Transfer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Physics and Astronomy Biophysics |
