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Insulin resistance is associated with depression risk in polycystic ovary syndrome
| Content Provider | Scilit |
|---|---|
| Author | Greenwood, Eleni A. Pasch, Lauri A. Cedars, Marcelle I. Legro, Richard S. Eisenberg, Esther Huddleston, Heather G. |
| Copyright Year | 2018 |
| Description | Journal: Fertility and sterility To test the hypothesis that insulin resistance is associated with depression risk in polycystic ovary syndrome (PCOS). Secondary analysis of data from a multicenter randomized trial. Multicenter university-based clinical practices. Seven hundred thirty-eight women with PCOS by modified Rotterdam criteria seeking pregnancy enrolled in a randomized clinical trial comparing clomiphene citrate versus letrozole. The Primary Care Evaluation of Mental Disorders Patient Health Questionnaire was self-administered to identify depression using a validated algorithm at enrollment. Demographic and anthropometric data were collected, and serum assays were performed. Insulin resistance was estimated using the homeostatic model of insulin resistance (HOMA-IR), with a cutoff of >2.2 considered abnormal. Demographic, endocrine, and metabolic parameters associated with depression. In a univariate logistic regression analysis, elevated HOMA-IR was associated with 2.3-fold increased odds of depression (odds ratio [OR] = 2.32; 95% confidence interval [CI], 1.28–4.21). This association remained significant after controlling for age and body mass index (adjusted OR [aOR] = 2.23; 95% CI, 1.11–4.46) and in a model including additional potential confounders (aOR = 2.03; 95% CI, 1.00–4.16). Insulin resistance has a strong and independent association with depression in PCOS and may serve as a physiologic mediator. Our findings corroborate a growing body of evidence linking insulin resistance to depressed mood. The association between insulin resistance and depressed mood warrants further investigation to elucidate mechanisms and identify potential therapeutic targets. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392023/pdf http://www.fertstert.org/article/S0015028218302620/pdf |
| Ending Page | 34 |
| Page Count | 8 |
| Starting Page | 27 |
| ISSN | 00150282 |
| e-ISSN | 15565653 |
| DOI | 10.1016/j.fertnstert.2018.03.009 |
| Journal | Fertility and sterility |
| Issue Number | 1 |
| Volume Number | 110 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2018-06-13 |
| Access Restriction | Open |
| Subject Keyword | Journal: Fertility and sterility Obstetrics and Gynecology Polycystic Ovary Syndrome (pcos) Insulin Resistance |
| Content Type | Text |
| Resource Type | Article |
| Subject | Reproductive Medicine Obstetrics and Gynecology |
