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Lipids, oxidized lipids, oxidation-specific epitopes, and Age-related Macular Degeneration
| Content Provider | Scilit |
|---|---|
| Author | Handa, James T. Cano, Marisol Wang, Lei Datta, Sayantan Liu, Tongyun |
| Copyright Year | 2016 |
| Description | Journal: Biochimica Et Biophysica Acta (bba) - Molecular and Cell Biology of Lipids Age-related Macular Degeneration (AMD) is the leading cause of blindness among the elderly in western societies. While antioxidant micronutrient treatment is available for intermediate non-neovascular disease, and effective anti-vascular endothelial growth factor treatment is available for neovascular disease, treatment for early AMD is lacking due to an incomplete understanding of the early molecular events. The role of lipids, which accumulate in the macula, and their oxidation, has emerged as an important factor in disease development. These oxidized lipids can either directly contribute to tissue injury or react with amine on proteins to form oxidation-specific epitopes, which can induce an innate immune response. If inadequately neutralized, the inflammatory response from these epitopes can incite tissue injury during disease development. This review explores how the accumulation of lipids, their oxidation, and the ensuing inflammatory response might contribute to the pathogenesis of AMD. This article is part of a Special Issue entitled: Lipid modification and lipid peroxidation products in innate immunity and inflammation edited by Christoph J. Binder . |
| Related Links | http://europepmc.org/articles/pmc5280582?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5280582/pdf |
| Ending Page | 440 |
| Page Count | 11 |
| Starting Page | 430 |
| ISSN | 13881981 |
| e-ISSN | 18792618 |
| DOI | 10.1016/j.bbalip.2016.07.013 |
| Journal | Biochimica Et Biophysica Acta (bba) - Molecular and Cell Biology of Lipids |
| Issue Number | 4 |
| Volume Number | 1862 |
| Language | English |
| Publisher | Elsevier BV |
| Publisher Date | 2016-07-30 |
| Access Restriction | Open |
| Subject Keyword | Journal: Biochimica Et Biophysica Acta (bba) - Molecular and Cell Biology of Lipids Age-related Macular Degeneration Bruch's Membrane Basal Deposits Very Low-density Lipoprotein (ldl) Oxidation-specific Epitopes Retinal Pigmented Epithelium (rpe) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology |
