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Giving blood: a new role for CD40 in tumorigenesis
| Content Provider | Scilit |
|---|---|
| Author | Bergmann, Stephan Pandolfi, Pier Paolo |
| Copyright Year | 2006 |
| Description | CD40 was initially identified as a receptor expressed by B cells that is crucial for inducing an effective adaptive immune response. CD40 was subsequently shown to be expressed by endothelial cells and to promote angiogenesis. New data now show that in tumor-prone transgenic mice, CD40-mediated neovascularization is essential for early stage tumorigenicity. This suggests, at least in this mouse model, that CD40 has an important role in the angiogenic process that is coupled to carcinogenesis, a finding that could lead to novel therapeutic opportunities. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118122/pdf http://jem.rupress.org/content/203/11/2409.full.pdf |
| Ending Page | 2412 |
| Page Count | 4 |
| Starting Page | 2409 |
| DOI | 10.1084/jem.20061754 |
| Journal | The Journal of experimental medicine |
| Issue Number | 11 |
| Volume Number | 203 |
| Language | English |
| Publisher | Rockefeller University Press |
| Publisher Date | 2006-10-30 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Angiogenic Carcinogenesis Model Tumorigenesis Adaptive Tumorigenicity Prone Neovascularization Cd40 Giving Journal: The Journal of experimental medicine (Vol- 203, Issue- 11) |
| Content Type | Text |
| Resource Type | Article |