NDLI: TGF-β and Eomes control the homeostasis of CD8+ regulatory T cells

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TGF-β and Eomes control the homeostasis of CD8+ regulatory T cells

Content Provider	Scilit
Author	Mishra, Shruti Liao, Wei Liu, Yong Yang, Ming Ma, Chaoyu Wu, Haijing Zhao, Ming Zhang, Xin Qiu, Yuanzheng Lu, Qianjin Zhang, Nu
Copyright Year	2020
Description	In addition to Foxp3+ CD4+ regulatory T cells (CD4+ T reg cells), Foxp3− CD8+ regulatory T cells (CD8+ T reg cells) are critical to maintain immune tolerance. However, the molecular programs that specifically control CD8+ but not CD4+ T reg cells are largely unknown. Here, we demonstrate that simultaneous disruption of both TGF-β receptor and transcription factor Eomesodermin (Eomes) in T cells results in lethal autoimmunity due to a specific defect in CD8+ but not CD4+ T reg cells. Further, TGF-β signal maintains the regulatory identity, while Eomes controls the follicular location of CD8+ T reg cells. Both TGF-β signal and Eomes coordinate to promote the homeostasis of CD8+ T reg cells. Together, we have identified a unique molecular program designed for CD8+ T reg cells.
Related Links	https://rupress.org/jem/article-pdf/218/1/e20200030/1050290/jem_20200030.pdf
DOI	10.1084/jem.20200030
Journal	The Journal of experimental medicine
Issue Number	1
Volume Number	218
Language	English
Publisher	Rockefeller University Press
Publisher Date	2021-01-04
Access Restriction	Open
Subject Keyword	Immunology Transcription Factor Cd8 Cd4 Regulatory Eomes Control Tgf Β Foxp3 Journal: The Journal of experimental medicine (Vol- 218, Issue- 1)
Content Type	Text

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