NDLI: In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes

Please wait, while we are loading the content...

In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes

Content Provider	Scilit
Author	Tang, Qizhi Henriksen, Kammi J. Bi, Mingying Finger, Erik B. Szot, Greg Ye, Jianqin Masteller, Emma L. McDevitt, Hugh Bonyhadi, Mark Bluestone, Jeffrey A.
Copyright Year	2004
Description	Journal: The Journal of experimental medicine The low number of CD4+ CD25+ regulatory T cells (Tregs), their anergic phenotype, and diverse antigen specificity present major challenges to harnessing this potent tolerogenic population to treat autoimmunity and transplant rejection. In this study, we describe a robust method to expand antigen-specific Tregs from autoimmune-prone nonobese diabetic mice. Purified CD4+ CD25+ Tregs were expanded up to 200-fold in less than 2 wk in vitro using a combination of anti-CD3, anti-CD28, and interleukin 2. The expanded Tregs express a classical cell surface phenotype and function both in vitro and in vivo to suppress effector T cell functions. Most significantly, small numbers of antigen-specific Tregs can reverse diabetes after disease onset, suggesting a novel approach to cellular immunotherapy for autoimmunity.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211775/pdf http://jem.rupress.org/content/199/11/1455.full.pdf
ISSN	00221295
DOI	10.1084/jem.20040139
Journal	The Journal of experimental medicine
Issue Number	11
Volume Number	199
Language	English
Publisher	Rockefeller University Press
Publisher Date	2004-06-07
Access Restriction	Open
Subject Keyword	Journal: The Journal of experimental medicine Autoimmunity Cd4+cd25+ T Cells Nod Mice Immunoregulation
Content Type	Text
Resource Type	Article
Subject	Physiology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in