NDLI: Mouse H-2k-restricted cytotoxic T cells recognize antigenic determinants in both the HA1 and HA2 subunits of the influenza A/PR/8/34 hemagglutinin.

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Mouse H-2k-restricted cytotoxic T cells recognize antigenic determinants in both the HA1 and HA2 subunits of the influenza A/PR/8/34 hemagglutinin.

Content Provider	Scilit
Author	Gould, Keith Scotney, H. Townsend, A. R. Bastin, J. Brownlee, G. G.
Copyright Year	1987
Description	Journal: The Journal of experimental medicine We have constructed two chimeric influenza hemagglutinin (HA) genes in which the HA1 and HA2 subunits of the HA molecule have been interchanged between influenza A/PR/8/34 (H1 subtype) and A/NT/60/68 (H3 subtype). These genes were used to construct recombinant vaccinia viruses that expressed intact chimeric HA. These recombinant viruses were used to test whether murine CTL recognize antigenic determinants in either the HA1, HA2, or both subunits. We found that both subunits of the HA molecule contain determinants for CTL. This implies that CTL have, at least in part, separate antigenic determinants from B lymphocytes, which recognize mainly epitopes within the HA1 subunit.
Related Links	http://jem.rupress.org/content/jem/166/3/693.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188694/pdf http://jem.rupress.org/content/166/3/693.full.pdf
ISSN	00221295
DOI	10.1084/jem.166.3.693
Journal	The Journal of experimental medicine
Issue Number	3
Volume Number	166
Language	English
Publisher	Rockefeller University Press
Publisher Date	1987-09-01
Access Restriction	Open
Subject Keyword	Journal: The Journal of experimental medicine Antigenic Determinants Influenza A/pr/8/34 Recognize Antigenic Ha Molecule Ha2 Subunits
Content Type	Text
Resource Type	Article
Subject	Physiology

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