NDLI: Increased IL-12 inhibits B cells' differentiation to germinal center cells and promotes differentiation to short-lived plasmablasts

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Increased IL-12 inhibits B cells' differentiation to germinal center cells and promotes differentiation to short-lived plasmablasts

Content Provider	Scilit
Author	Kim, Sun Jung Caton, Michele Wang, Chuansheng Khalil, Magi Zhou, Zhi-Jie Hardin, John Diamond, Betty
Copyright Year	2008
Description	B cells activated by antigen in T cell–dependent immune responses can become short-lived plasma cells, which remain in the spleen, or germinal center–derived memory or plasma cells, which show evidence of affinity maturation and, in the case of plasma cells, migrate to the bone marrow. We show that this cell fate decision can be governed by the cytokine environment engendered by activated dendritic cells (DCs). DCs from mice lacking the Fc receptor γ chain exhibited an activated phenotype in vitro. They secreted more of the proinflammatory cytokine IL-12, which led to the preferential generation of short-lived splenic plasma cells, with ensuing low affinity antibodies and a diminished recall response. Understanding the factors that regulate antigen-activated B cell differentiation and memory cell formation has implications for both antibody-mediated autoimmune disease and protective antibody responses.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556778/pdf http://jem.rupress.org/content/205/10/2437.full.pdf
Ending Page	2448
Page Count	12
Starting Page	2437
DOI	10.1084/jem.20070731
Journal	The Journal of experimental medicine
Issue Number	10
Volume Number	205
Language	English
Publisher	Rockefeller University Press
Publisher Date	2008-09-29
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Antibody Differentiation Bone Marrow Dcs Germinal Lived Antigen Activated B Cell Journal: The Journal of experimental medicine (Vol- 205, Issue- 10)
Content Type	Text

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