NDLI: Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis

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Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis

Content Provider	Scilit
Author	Collins, Amélie Mitchell, Carl A. Passegué, Emmanuelle
Copyright Year	2021
Description	Inflammation exerts multiple effects on the early hematopoietic compartment. Best studied is the role of proinflammatory cytokines in activating adult hematopoietic stem and progenitor cells to dynamically replenish myeloid lineage cells in a process known as emergency myelopoiesis. However, it is increasingly appreciated that the same proinflammatory signaling pathways are used in diverse hematopoietic scenarios. This review focuses on inflammatory signaling in the emergence of the definitive hematopoietic compartment during embryonic life, and tonic inflammatory signals derived from commensal microbiota in shaping the adult hematopoietic compartment in the absence of pathogenic insults. Insights into the unique and shared aspects of inflammatory signaling that regulate hematopoietic stem and progenitor cell function across the lifespan and health span of an individual will enable better diagnostic and therapeutic approaches to hematopoietic dysregulation and malignancies.
Related Links	https://rupress.org/jem/article-pdf/218/7/e20201545/1417918/jem_20201545.pdf
DOI	10.1084/jem.20201545
Journal	The Journal of experimental medicine
Issue Number	7
Volume Number	218
Language	English
Publisher	Rockefeller University Press
Publisher Date	2021-06-15
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Adult Progenitor Cell Hematopoietic Compartment Inflammatory Signaling Regulates Stem Diverse Journal: The Journal of experimental medicine (Vol- 218, Issue- 7)
Content Type	Text

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