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Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS
| Content Provider | Scilit |
|---|---|
| Author | Trowbridge, Jennifer J. Starczynowski, Daniel T. |
| Copyright Year | 2021 |
| Description | With a growing aged population, there is an imminent need to develop new therapeutic strategies to ameliorate disorders of hematopoietic aging, including clonal hematopoiesis and myelodysplastic syndrome (MDS). Cell-intrinsic dysregulation of innate immune- and inflammatory-related pathways as well as systemic inflammation have been implicated in hematopoietic defects associated with aging, clonal hematopoiesis, and MDS. Here, we review and discuss the role of dysregulated innate immune and inflammatory signaling that contribute to the competitive advantage and clonal dominance of preleukemic and MDS-derived hematopoietic cells. We also propose how emerging concepts will further reveal critical biology and novel therapeutic opportunities. |
| Related Links | https://rupress.org/jem/article-pdf/218/7/e20201544/1417911/jem_20201544.pdf |
| DOI | 10.1084/jem.20201544 |
| Journal | The Journal of experimental medicine |
| Issue Number | 7 |
| Volume Number | 218 |
| Language | English |
| Publisher | Rockefeller University Press |
| Publisher Date | 2021-06-15 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Innate Immune Mds Clonal Hematopoiesis Dysregulation Hematopoietic Aging Journal: The Journal of experimental medicine (Vol- 218, Issue- 7) |
| Content Type | Text |