NDLI: T cell development. Precursors and inducer requirements of helper effector and feedback suppression inducer cell sets.

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T cell development. Precursors and inducer requirements of helper effector and feedback suppression inducer cell sets.

Content Provider	Scilit
Author	Shen, F. W. McDougal, J. S. Bard, J. Cort, S. P.
Copyright Year	1981
Description	The surface phenotypes and differentiative history of specific helper-effector (HE) and specific feedback suppression-inducer (FBSI) cell sets were further defined in reference to the Qa-1 and I-J marker systems by culture of selected sets of cortisone-resistant nylon-purified thymocytes with antigen on primed macrophages. The generation of Ly-1:HE and Ly-1:FBSI cell sets required, in each case, two initiating sets: a precursor set and a differentiation-inducing set. Precursor sets were distinguished from inducer sets by genetic markers. Accordingly, HE cells, phenotype Ly-1:Qa-1-:I-J-, differentiated from Ly-123:Qa-1- cells in the presence of Ly-1:Qa-1+:I-J+ inducer cells; and FBSI cells, phenotype Ly-1:Qa-1+:I-J+, differentiated from Ly-123:Qa-1- in the presence of Ly-1:Qa-1+:I-J+ inducer cells. The Ly-123:Qa-1-precursors of HE and FBSI cells have been distinguished from one another previously but there is as yet no evidence whether differentiation of these precursor sets requires the same or different Ly-1:Qa-1+:I-J+ inducer sets.
Related Links	http://jem.rupress.org/content/154/3/935.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186464/pdf
Ending Page	941
Page Count	7
Starting Page	935
DOI	10.1084/jem.154.3.935
Journal	The Journal of experimental medicine
Issue Number	3
Volume Number	154
Language	English
Publisher	Rockefeller University Press
Publisher Date	1981-09-01
Access Restriction	Open
Subject Keyword	Immunology Differentiation Feedback Precursor Antigen Helper Cell Sets Inducer Cells Fbsi Journal: The Journal of experimental medicine (Vol- 154, Issue- 3)
Content Type	Text

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