NDLI: STUDIES ON THE PATHOGENESIS OF FEVER

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STUDIES ON THE PATHOGENESIS OF FEVER

Content Provider	Scilit
Author	Rafter, Gale W. Collins, Robert D. Wood, W. Barry
Copyright Year	1960
Description	Study of the chemical properties of the pyrogenic component of rabbit polymorphonuclear leucocytes reveals it to contain an essential, non-dialyzable protein which: (a) is precipitated by perchloric acid, (b) is removed by extraction with phenol, (c) is soluble in 50 per cent methanol and 33 per cent saturated ammonium sulfate, and (d) is destroyed by the proteolytic action of both trypsin and pepsin. By combined chemical and chromatographic techniques the leucocytic pyrogen has been purified approximately 50-fold. The partially purified material contains less than 1 per cent carbohydrate, is resistant to periodate oxidation, is unaffected by extraction with butanol and contains at least two immunologically active components when tested by the Ouchterlony gel-diffusion technique. Its chemical properties distinguish it from other known pyrogenic substances which have been implicated in the pathogenesis of fever.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137288/pdf http://jem.rupress.org/content/111/6/831.full.pdf
Ending Page	840
Page Count	10
Starting Page	831
DOI	10.1084/jem.111.6.831
Journal	The Journal of experimental medicine
Issue Number	6
Volume Number	111
Language	English
Publisher	Rockefeller University Press
Publisher Date	1960-06-01
Access Restriction	Open
Subject Keyword	Fever/experimental Pyrogens/chemistry Journal: The Journal of experimental medicine (Vol- 111, Issue- 6)
Content Type	Text

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