NDLI: Early aging–associated phenotypes in Bub3/Rae1 haploinsufficient mice

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Early aging–associated phenotypes in Bub3/Rae1 haploinsufficient mice

Content Provider	Scilit
Author	Baker, Darren J. Jeganathan, Karthik Malureanu, Liviu Perez-Terzic, Carmen Terzic, Andre Deursen, Jan M. A. Van
Copyright Year	2006
Description	Journal: Journal of Cell Biology Aging is a highly complex biological process that is believed to involve multiple mechanisms. Mice that have small amounts of the mitotic checkpoint protein BubR1 age much faster than normal mice, but whether other mitotic checkpoint genes function to prevent the early onset of aging is unknown. In this study, we show that several aging-associated phenotypes appear early in mice that are double haploinsufficient for the mitotic checkpoint genes Bub3 and Rae1 but not in mice that are single haploinsufficient for these genes. Mouse embryonic fibroblasts (MEFs) from Bub3/Rae1 haploinsufficient mice undergo premature senescence and accumulate high levels of p19, p53, p21, and p16, whereas MEFs from single haploinsufficient mice do not. Furthermore, although BubR1 hypomorphic mice have less aneuploidy than Bub3/Rae1 haploinsufficient mice, they age much faster. Our findings suggest that early onset of aging-associated phenotypes in mice with mitotic checkpoint gene defects is linked to cellular senescence and activation of the p53 and p16 pathways rather than to aneuploidy.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063673/pdf http://jcb.rupress.org/content/172/4/529.full.pdf
ISSN	00221295
DOI	10.1083/jcb.200507081
Journal	Journal of Cell Biology
Issue Number	4
Volume Number	172
Language	English
Publisher	Rockefeller University Press
Publisher Date	2006-02-13
Access Restriction	Open
Subject Keyword	Journal: Journal of Cell Biology Research and Experimental Medicine Mitotic Checkpoint Genes Bub3/rae1 Haploinsufficient Mice
Content Type	Text
Resource Type	Article
Subject	Physiology

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