NDLI: Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy

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Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy

Content Provider	Scilit
Author	Mejlvang, Jakob Olsvik, Hallvard Svenning, Steingrim Bruun, Jack-Ansgar Abudu, Yakubu Princely Larsen, Kenneth Bowitz Brech, Andreas Hansen, Tom E. Brenne, Hanne Hansen, Terkel Stenmark, Harald Johansen, Terje
Copyright Year	2018
Description	Journal: Journal of Cell Biology It is not clear to what extent starvation-induced autophagy affects the proteome on a global scale and whether it is selective. In this study, we report based on quantitative proteomics that cells during the first 4 h of acute starvation elicit lysosomal degradation of up to 2–3% of the proteome. The most significant changes are caused by an immediate autophagic response elicited by shortage of amino acids but executed independently of mechanistic target of rapamycin and macroautophagy. Intriguingly, the autophagy receptors p62/SQSTM1, NBR1, TAX1BP1, NDP52, and NCOA4 are among the most efficiently degraded substrates. Already 1 h after induction of starvation, they are rapidly degraded by a process that selectively delivers autophagy receptors to vesicles inside late endosomes/multivesicular bodies depending on the endosomal sorting complex required for transport III (ESCRT-III). Our data support a model in which amino acid deprivation elicits endocytosis of specific membrane receptors, induction of macroautophagy, and rapid degradation of autophagy receptors by endosomal microautophagy.
Related Links	https://rupress.org/jcb/article-pdf/217/10/3640/746640/jcb_201711002.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168274/pdf http://jcb.rupress.org/content/early/2018/07/16/jcb.201711002.full.pdf
ISSN	00221295
DOI	10.1083/jcb.201711002
Journal	Journal of Cell Biology
Issue Number	10
Volume Number	217
Language	English
Publisher	Rockefeller University Press
Publisher Date	2018-07-17
Access Restriction	Open
Subject Keyword	Journal: Journal of Cell Biology Cell Biology Autophagy Receptors Microautophagy Macroautophagy
Content Type	Text
Resource Type	Article
Subject	Physiology

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