NDLI: Interference with Immunoglobulin (Ig)α Immunoreceptor Tyrosine–Based Activation Motif (Itam) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Igβ Cytoplasmic Tail

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Interference with Immunoglobulin (Ig)α Immunoreceptor Tyrosine–Based Activation Motif (Itam) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Igβ Cytoplasmic Tail

Content Provider	Scilit
Author	Kraus, Manfred Pao, Lily I. Reichlin, Amy Hu, Yun Canono, Beth Cambier, John C. Nussenzweig, Michel C. Rajewsky, Klaus
Copyright Year	2001
Description	Journal: The Journal of experimental medicine To determine the function of immunoglobulin (Ig)α immunoreceptor tyrosine–based activation motif (ITAM) phosphorylation, we generated mice in which Igα ITAM tyrosines were replaced by phenylalanines (IgαFF/FF). IgαFF/FFmice had a specific reduction of B1 and marginal zone B cells, whereas B2 cell development appeared to be normal, except that λ1 light chain usage was increased. The mutants responded less efficiently to T cell–dependent antigens, whereas T cell–independent responses were unaffected. Upon B cell receptor ligation, the cells exhibited heightened calcium flux, weaker Lyn and Syk tyrosine phosphorylation, and phosphorylation of Igα non-ITAM tyrosines. Strikingly, when the Igα ITAM mutation was combined with a truncation of Igβ, B cell development was completely blocked at the pro-B cell stage, indicating a crucial role of ITAM phosphorylation in B cell development.
Related Links	http://jem.rupress.org/content/194/4/455.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193498/pdf http://jem.rupress.org/content/jem/194/4/455.full.pdf
ISSN	00221295
DOI	10.1084/jem.194.4.455
Journal	The Journal of experimental medicine
Issue Number	4
Volume Number	194
Language	English
Publisher	Rockefeller University Press
Publisher Date	2001-08-20
Access Restriction	Open
Subject Keyword	Journal: The Journal of experimental medicine Mb-1 Protein B Cell Antigen Receptor B Cell Subsets Gene Targeting
Content Type	Text
Resource Type	Article
Subject	Physiology

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