NDLI: Interleukin 7 generates antitumor cytotoxic T lymphocytes against murine sarcomas with efficacy in cellular adoptive immunotherapy.

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Interleukin 7 generates antitumor cytotoxic T lymphocytes against murine sarcomas with efficacy in cellular adoptive immunotherapy.

Content Provider	Scilit
Author	Jicha, Douglas L. Mul, James J. Rosenberg, Steven A.
Copyright Year	1991
Description	Interleukin 7 (IL-7) is a 25-kD cytokine that was initially described as a pre-B cell growth factor. This cytokine has also been shown to have T cell proliferative and differentiation effects. In this report, we demonstrate that antitumor cytotoxic T lymphocytes (CTL) generated by secondary in vitro sensitization of draining lymph node cells in IL-7 are effective in treating 3-day syngeneic methylcholanthrene (MCA) sarcoma pulmonary metastases in mice. In vivo titrations comparing IL-7 to IL-2 antitumor CTL show that they have equivalent potency in adoptive immunotherapy. IL-7 antitumor CTL generated against MCA sarcomas of weak immunogeneity are also tumor specific in their in vivo efficacy. This study represents the first successful use of a cytokine other than IL-2 for the generation of cells with in vivo efficacy in cellular adoptive transfer.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119035/pdf http://jem.rupress.org/content/174/6/1511.full.pdf
Ending Page	1515
Page Count	5
Starting Page	1511
DOI	10.1084/jem.174.6.1511
Journal	The Journal of experimental medicine
Issue Number	6
Volume Number	174
Language	English
Publisher	Rockefeller University Press
Publisher Date	1991-12-01
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Differentiation Immunotherapy Efficacy Lymphocytes Antitumor Mca Sarcomas Cytotoxic Ctl Vivo Journal: The Journal of experimental medicine (Vol- 174, Issue- 6)
Content Type	Text

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