NDLI: FURTHER EXPERIMENTS ON ACTIVE IMMUNIZATION AGAINST TYPHUS FEVER WITH KILLED RICKETTSIA

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FURTHER EXPERIMENTS ON ACTIVE IMMUNIZATION AGAINST TYPHUS FEVER WITH KILLED RICKETTSIA

Content Provider	Scilit
Author	Zinsser, Hans Castaneda, M. Ruiz
Copyright Year	1933
Description	1. Vaccines consisting of formalinized Rickettsiae of Mexican typhus fever, obtained by our X-ray rat method, produce definite resistance in guinea pigs to subsequent infection with the virus of this disease. 2. The resistance so produced amounts to complete immunity when the subsequent infectious dose is moderate—that is, consists of typhus blood or of tunica material in reasonable amounts (not more than one-quarter of a tunica—i.e., roughly 100 to 250 infectious doses). When, as in the first experiment, excessive doses of infectious material were given, the vaccination protection was, in two of the three animals, incomplete. 3. Subcutaneous vaccination is fully as effective as intraperitoneal —even when the subsequent infection is intraperitoneal. 4. As in previously reported experiments, the vaccines made with the Mexican organisms conferred only partial and feeble protection against the European virus (Breinl strain).
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132240/pdf
Ending Page	390
Page Count	10
Starting Page	381
DOI	10.1084/jem.57.3.381
Journal	The Journal of experimental medicine
Issue Number	3
Volume Number	57
Language	English
Publisher	Rockefeller University Press
Publisher Date	1933-03-01
Access Restriction	Open
Subject Keyword	Infectious Diseases Bioinformatics Biomedical Research Journal: The Journal of experimental medicine (Vol- 57, Issue- 3)
Content Type	Text

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