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REGULATION OF THE IMMUNE RESPONSE
| Content Provider | Scilit |
|---|---|
| Author | Kappler, John W. Hoffmann, Michael J. |
| Copyright Year | 1973 |
| Description | The kinetics of the in vivo response to SRBC was studied in mouse spleen at both the B cell and T cell levels. The B cell response was assayed by following the appearance of antibody-secreting cells in the spleen using the hemolytic plaque assay. The T cell response was monitored by following the increase in or "priming" of helper activity in the spleen using a quantitative in vitro assay. The role of cellular proliferation in both responses was established with the inhibitor of mitosis, vinblastine. The results show that, although the development of T cell activity precedes that of anti-SRBC PFC by as much as 1 day, T cells lag at least 1 day behind B cells in the onset of cellular proliferation. The evidence suggests either that the helper T cell which proliferates in response to SRBC does so after helping in the initiation of the primary B cell response or that the proliferative T cell response and the initiation of the primary B cell response involve two different subpopulations of T cells. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139343/pdf |
| Ending Page | 1337 |
| Page Count | 13 |
| Starting Page | 1325 |
| DOI | 10.1084/jem.137.6.1325 |
| Journal | The Journal of experimental medicine |
| Issue Number | 6 |
| Volume Number | 137 |
| Language | English |
| Publisher | Rockefeller University Press |
| Publisher Date | 1973-06-01 |
| Access Restriction | Open |
| Subject Keyword | Peripheral Vascular Disease Immune Response Kinetics Journal: The Journal of experimental medicine (Vol- 137, Issue- 6) |
| Content Type | Text |
