NDLI: Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies

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Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies

Content Provider	Scilit
Author	Ehrenstein, Michael Cook, H. Terence Neuberger, Michael S.
Copyright Year	2000
Description	Serum immunoglobulin (Ig)M provides the initial response to foreign antigen and plays a regulatory role in subsequent immune response development, accelerating the production of high-affinity IgG. Here we show that mice deficient in serum IgM have an increased propensity to spontaneous autoimmunity as judged by the development with age of serum IgG anti-DNA antibodies and the renal deposition of IgG and complement. They also exhibit augmented anti-DNA IgG production on exposure to lipopolysaccharide. Thus, deficiency in serum IgM leads to diminished responsiveness to foreign antigens but increased responsiveness to self—a paradoxical association reminiscent of that described in humans deficient in complement or IgA. We wondered whether serum IgM might play an analogous role with regard to the response to self-antigens. However, here—in contrast to the sluggish response to foreign antigens—we find that deficiency in serum IgM actually predisposes to the development of IgG antibodies to autoantigens.
Related Links	http://jem.rupress.org/content/191/7/1253.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193170/pdf http://jem.rupress.org/content/jem/191/7/1253.full.pdf
Ending Page	1258
Page Count	6
Starting Page	1253
DOI	10.1084/jem.191.7.1253
Journal	The Journal of experimental medicine
Issue Number	7
Volume Number	191
Language	English
Publisher	Rockefeller University Press
Publisher Date	2000-04-03
Access Restriction	Open
Subject Keyword	Immunology Immunodeficiency Autoimmunity B Lymphocyte Secretory Igm Journal: The Journal of experimental medicine (Vol- 191, Issue- 7)
Content Type	Text

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