NDLI: Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin.

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Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin.

Content Provider	Scilit
Author	Marchese, C. Chedid, M. Dirsch, O. R. Csaky, K. G. Santanelli, F. Latini, C. LaRochelle, W. J. Torrisi, M. R. Aaronson, S. A.
Copyright Year	1995
Description	We investigated the expression and distribution of keratinocyte growth factor (KGF) (FGF-7) and its receptor (KGFR) during reepithelialization of human skin. KGF mRNA levels increased rapidly by 8-10-fold and remained elevated for several days. In contrast, KGFR transcript levels decreased early but were significantly elevated by 8-9 d. A KGF-immunoglobulin G fusion protein (KGF-HFc), which specifically and sensitively detects the KGFR, localized the receptor to differentiating keratinocytes of control epidermis, but revealed a striking decrease in receptor protein expression during the intermediate period of reepithelization. Suramin, which blocked KGF binding and stripped already bound KGF from its receptor, failed to unmask KGFRs in tissue sections from the intermediate phase of wound repair. The absence of KGFR protein despite increased KGFR transcript levels implies functional receptor downregulation in the presence of increased KGF. This temporal modulation of KGF and KGFRs provides strong evidence for the functional involvement of KGF in human skin reepithelialization.
Related Links	http://jem.rupress.org/content/jem/182/5/1369.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192199/pdf
Ending Page	1376
Page Count	8
Starting Page	1369
DOI	10.1084/jem.182.5.1369
Journal	The Journal of experimental medicine
Issue Number	5
Volume Number	182
Language	English
Publisher	Rockefeller University Press
Publisher Date	1995-11-01
Access Restriction	Open
Subject Keyword	Developmental Biology Gene Expression Regulation Cell Differentiation Fibroblast Growth Factor 10 Down Regulation Fibroblast Growth Factors Epidermis Journal: The Journal of experimental medicine (Vol- 182, Issue- 5)
Content Type	Text

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