NDLI: Intercellular Transfer and Supramolecular Organization of Human Leukocyte Antigen C at Inhibitory Natural Killer Cell Immune Synapses✪

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Intercellular Transfer and Supramolecular Organization of Human Leukocyte Antigen C at Inhibitory Natural Killer Cell Immune Synapses✪

Content Provider	Scilit
Author	Carlin, Leo Eleme, Konstantina McCann, Fiona Davis, Daniel
Copyright Year	2001
Description	Journal: The Journal of experimental medicine After accumulation of target cell human leukocyte antigen (HLA)-C at inhibitory natural killer (NK) cell immune synapses, some HLA-C transfers from target cells to NK cell plasma membranes and cytoplasm. This unexpected intercellular transfer of HLA-C is dependent on NK receptor recognition, since HLA-Cw6 or -Cw4 but not -Cw3 transfer to an NK transfectant expressing killer Ig-like receptor (KIR)2DL1. Strikingly, live-cell time-lapse laser scanning confocal microscopy shows vesicles containing target cell green fluorescent protein–tagged HLA-C migrating away from immune synapses into NK cells. Unlike clustering of HLA-C at the immune synapse, intercellular transfer of HLA-C is dependent on NK cell ATP, but not target cell ATP. However, the intercellular transfer of HLA-C is not dependent on active polymerization of the actin cytoskeleton. In addition, different arrangements of HLA-C are seen at inhibitory NK immune synapses, and these alter as NK synapses mature, but in a fashion distinct from that seen upon T cell activation.
Related Links	http://jem.rupress.org/content/194/10/1507.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193674/pdf
ISSN	00221295
DOI	10.1084/jem.194.10.1507
Journal	The Journal of experimental medicine
Issue Number	10
Volume Number	194
Language	English
Publisher	Rockefeller University Press
Publisher Date	2001-11-19
Access Restriction	Open
Subject Keyword	Journal: The Journal of experimental medicine Intercellular Transfer Immune Synapses
Content Type	Text
Resource Type	Article
Subject	Physiology

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