NDLI: Adhesion, growth, and matrix production by fibroblasts on laminin substrates.

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Adhesion, growth, and matrix production by fibroblasts on laminin substrates.

Content Provider	Scilit
Author	Couchman, J. R. Höök, M. Rees, D. A. Timpl, R.
Copyright Year	1983
Description	Human embryonic skin fibroblasts have been shown to attach and spread on laminin substrates in the absence of protein synthesis and presence of fibronectin-depleted serum and anti-fibronectin antibodies. Rates of attachment and the type of spreading are virtually identical on fibronectin and laminin-coated substrates with the development of microfilament bundles and focal adhesions. Antibodies to laminin, but not fibronectin, will prevent or reverse fibroblast adhesion to laminin, whereas antibodies to fibronectin but not laminin will give similar results on fibronectin-coated substrates. These and other results indicate that fibroblasts possess distinct receptors for laminin and fibronectin which on contact with suitable substrates promote adhesion through interaction with common intermediates. This type of adhesion is compatible with subsequent growth and extracellular matrix production.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2112271/pdf
Ending Page	183
Page Count	7
Starting Page	177
DOI	10.1083/jcb.96.1.177
Journal	Journal of Cell Biology
Issue Number	1
Volume Number	96
Language	English
Publisher	Rockefeller University Press
Publisher Date	1983-01-01
Access Restriction	Open
Subject Keyword	Protein Antibodies Adhesion Fibronectin Fibroblasts Attachment Laminin Substrates Spreading Coated Journal: Journal of Cell Biology (Vol- 96, Issue- 1)
Content Type	Text

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