NDLI: The Ras protein superfamily: Evolutionary tree and role of conserved amino acids

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The Ras protein superfamily: Evolutionary tree and role of conserved amino acids

Content Provider	Scilit
Author	Rojas, Ana Maria Fuentes, Gloria Rausell, Antonio Valencia, Alfonso
Copyright Year	2012
Description	The Ras superfamily is a fascinating example of functional diversification in the context of a preserved structural framework and a prototypic GTP binding site. Thanks to the availability of complete genome sequences of species representing important evolutionary branch points, we have analyzed the composition and organization of this superfamily at a greater level than was previously possible. Phylogenetic analysis of gene families at the organism and sequence level revealed complex relationships between the evolution of this protein superfamily sequence and the acquisition of distinct cellular functions. Together with advances in computational methods and structural studies, the sequence information has helped to identify features important for the recognition of molecular partners and the functional specialization of different members of the Ras superfamily.
Related Links	https://rupress.org/jcb/article-pdf/196/2/189/701978/jcb_201103008.pdf https://core.ac.uk/reader/80868103 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265948/pdf http://jcb.rupress.org/content/196/2/189.full.pdf
Ending Page	201
Page Count	13
Starting Page	189
DOI	10.1083/jcb.201103008
Journal	Journal of Cell Biology
Issue Number	2
Volume Number	196
Language	English
Publisher	Rockefeller University Press
Publisher Date	2012-01-23
Access Restriction	Open
Subject Keyword	Evolutionary Biology Functional Structural Protein Superfamily Evolutionary Sequence Ras Superfamily Journal: Journal of Cell Biology (Vol- 196, Issue- 2)
Content Type	Text
Resource Type	Article

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