NDLI: Spermatozoa capture HIV-1 through heparan sulfate and efficiently transmit the virus to dendritic cells

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Spermatozoa capture HIV-1 through heparan sulfate and efficiently transmit the virus to dendritic cells

Content Provider	Scilit
Author	Ceballos, Ana Lenicov, Federico Remes Sabatté, Juan Rodrigues, Christian Rodriguez Cabrini, Mercedes Jancic, Carolina Raiden, Silvina Donaldson, Mónica Pasqualini, Rodolfo Agustín Marin-Briggiler, Clara Vazquez-Levin, Mónica Capani, Francisco Amigorena, Sebastian Geffner, Jorge
Copyright Year	2009
Description	Semen is the main vector for HIV-1 dissemination worldwide. It contains three major sources of infectious virus: free virions, infected leukocytes, and spermatozoa-associated virions. We focused on the interaction of HIV-1 with human spermatozoa and dendritic cells (DCs). We report that heparan sulfate is expressed in spermatozoa and plays an important role in the capture of HIV-1. Spermatozoa-attached virus is efficiently transmitted to DCs, macrophages, and T cells. Interaction of spermatozoa with DCs not only leads to the transmission of HIV-1 and the internalization of the spermatozoa but also results in the phenotypic maturation of DCs and the production of IL-10 but not IL-12p70. At low values of extracellular pH (∼6.5 pH units), similar to those found in the vaginal mucosa after sexual intercourse, the binding of HIV-1 to the spermatozoa and the consequent transmission of HIV-1 to DCs were strongly enhanced. Our observations support the notion that far from being a passive carrier, spermatozoa acting in concert with DCs might affect the early course of sexual transmission of HIV-1 infection.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806607/pdf
Ending Page	2733
Page Count	17
Starting Page	2717
DOI	10.1084/jem.20091579
Journal	The Journal of experimental medicine
Issue Number	12
Volume Number	206
Language	English
Publisher	Rockefeller University Press
Publisher Date	2009-10-26
Access Restriction	Open
Subject Keyword	Virology Virus Hiv Virions Spermatozoa Sulfate Capture Sexual Dcs Dendritic Heparan Journal: The Journal of experimental medicine (Vol- 206, Issue- 12)
Content Type	Text

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