NDLI: Cytotoxic T-cell activation by polyribonucleotides: DNA synthesis is not required.

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Cytotoxic T-cell activation by polyribonucleotides: DNA synthesis is not required.

Content Provider	Scilit
Author	Bick, P. H. Möller, G.
Copyright Year	1977
Description	We have shown that cytotoxic T cells can be polyclonally activated by a short exposure to complexes of polyadenylic:polyuridylic acid (poly A:U). Activation is optimal at a dose of 100 microgram/ml poly A:U and occurs during a 2 h incubation period in the absence of antigen. Killing of allogeneic, but not syngeneic, target cells can be observed after 12 h in culture and peaks after 21-24 h in the absence of any nonspecific binding ligand. The observed cytotoxicity is mediated by T lymphocytes and dose not require accessory macrophages or DNA synthesis for the activation or expression of effector functions. These results suggest that few requirements exist for the activation of cytotoxic T cells.
Related Links	http://jem.rupress.org/content/146/3/844.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180786/pdf
Ending Page	856
Page Count	13
Starting Page	844
DOI	10.1084/jem.146.3.844
Journal	The Journal of experimental medicine
Issue Number	3
Volume Number	146
Language	English
Publisher	Rockefeller University Press
Publisher Date	1977-09-01
Access Restriction	Open
Subject Keyword	Biochemistry and Molecular Biology Immunology Lymphocytes Functions Allogeneic Antigen Optimal Dna Synthesis Cytotoxic Incubation Syngeneic Poly Journal: The Journal of experimental medicine (Vol- 146, Issue- 3)
Content Type	Text

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