NDLI: Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice.

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Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice.

Content Provider	Scilit
Author	Grillot, D. A. Merino, Ramon Núñez, G.
Copyright Year	1995
Description	The survival of T lymphocytes is tightly controlled during development. Here, we show that Bcl-xL, a protein homologue of Bcl-2, is highly regulated in the thymus in a pattern different than that of Bcl-2. The maximum expression was in CD4+CD8+ thymocytes, a developmental stage where Bcl-2 is downregulated. To assess the role of Bcl-xL in thymocyte apoptosis, we generated mice overexpressing an E mu-bcl-x transgene within the T cell compartment. Constitutive expression of Bcl-xL resulted in accumulation of thymocytes and mature T cells in lymphoid organs. Thymocytes overexpressing Bcl-xL exhibited increased viability in vitro and were resistant to apoptosis induced by different signals, including glucocorticoid, gamma irradiation, calcium ionophore, and CD3 cross-linking. However, Bcl-xL was unable to block clonal deletion of thymocytes reactive with self-superantigens or H-Y antigen. These studies demonstrate that Bcl-2 and Bcl-xL, two functionally related proteins, are regulated independently during T cell development. In contrast to Bcl-2, which has been implicated in the maintenance of mature T cells, Bcl-xL appears to provide a survival signal for the maintenance of more immature CD4+CD8+ thymocytes before positive selection.
Related Links	http://jem.rupress.org/content/182/6/1973.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192263/pdf
Ending Page	1983
Page Count	11
Starting Page	1973
DOI	10.1084/jem.182.6.1973
Journal	The Journal of experimental medicine
Issue Number	6
Volume Number	182
Language	English
Publisher	Rockefeller University Press
Publisher Date	1995-12-01
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Apoptosis Survival Viability Proteins Antigen Maintenance Bcl Xl Overexpressing Journal: The Journal of experimental medicine (Vol- 182, Issue- 6)
Content Type	Text

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