NDLI: A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97.

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A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97.

Content Provider	Scilit
Author	Furukawa, K. S. Real, Francisco X. Lloyd, K. O.
Copyright Year	1989
Description	Analysis of antibodies present in the serum of melanoma patient FD has shown that they detect a unique tumor epitope present only on the autologous melanoma cell line SK-MEL-131. Previous results had shown that the unique FD epitope is carried on a common glycoprotein of approximately 90 kD, widely expressed on melanoma and a few other cell types. We now show by sequential radioimmunoprecipitation and partial amino acid sequencing that this common molecule is a previously recognized melanoma antigen, originally identified by mouse mAbs, designated gp95 or p97 (and also known as melanotransferrin). Thus, FD is the first of the class I (unique) melanoma antigens that has been characterized and related to a known cell surface molecule.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189208/pdf http://jem.rupress.org/content/169/2/585.full.pdf
Ending Page	590
Page Count	6
Starting Page	585
DOI	10.1084/jem.169.2.585
Journal	The Journal of experimental medicine
Issue Number	2
Volume Number	169
Language	English
Publisher	Rockefeller University Press
Publisher Date	1989-02-01
Access Restriction	Open
Subject Keyword	Biochemistry and Molecular Biology Antibodies Glycoprotein Cell Epitope Molecule Unique Antigenic Melanoma Antigens Journal: The Journal of experimental medicine (Vol- 169, Issue- 2)
Content Type	Text

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