NDLI: Somatically mutated forms of a major anti-p-azophenylarsonate antibody variable region with drastically reduced affinity for p-azophenylarsonate. By-products of an antigen-driven immune response?

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Somatically mutated forms of a major anti-p-azophenylarsonate antibody variable region with drastically reduced affinity for p-azophenylarsonate. By-products of an antigen-driven immune response?

Content Provider	Scilit
Author	Manser, T. Parhami-Seren, B. Margolies, Mn Gefter, Ml
Copyright Year	1987
Description	Journal: The Journal of experimental medicine The pivotal role played by antigen in the clonal selection of B cells for initial participation in an immune response is well established. Antigen selective mechanisms ensure that antigen-binding antibodies are produced during all stages of the immune response. However, antibodies that lack specificity for the immunogen might also be produced during the course of an antigen-driven immune response . It has been suggested that, through idiotype-antiidiotype network interactions within the immune system, production of antibodies that lack specificity for the immunogen but that share idiotopes with antigen-binding antibodies could result (1). In addition, data obtained by a number of investigators suggest that somatic mutation of antibody V region genes occurs at a rate of 10(-3)/basepair/cell division in B cells participating in an immune response (2, 3). One outcome of such V region structural alteration could be antibodies that lack, or have drastically reduced affinity for the immunogen . We sought to identify and characterize some of the antibody by-products of the antigen-driven immune response that are expected to be created by the mechanisms described above.
Related Links	http://jem.rupress.org/content/jem/166/5/1456.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189635/pdf http://jem.rupress.org/content/166/5/1456.full.pdf
ISSN	00221295
DOI	10.1084/jem.166.5.1456
Journal	The Journal of experimental medicine
Issue Number	5
Volume Number	166
Language	English
Publisher	Rockefeller University Press
Publisher Date	1987-11-01
Access Restriction	Open
Subject Keyword	Journal: The Journal of experimental medicine Somatic Mutation Drastically Reduced Affinity Azophenylarsonate
Content Type	Text
Resource Type	Article
Subject	Physiology

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