NDLI: THE EFFECT OF THE HYDROGEN ION CONCENTRATION ON THE RATE OF HYDROLYSIS OF GLYCYL GLYCINE, GLYCYL LEUCINE, GLYCYL ALANINE, GLYCYL ASPARAGINE, GLYCYL ASPARTIC ACID, AND BIURET BASE BY EREPSIN

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THE EFFECT OF THE HYDROGEN ION CONCENTRATION ON THE RATE OF HYDROLYSIS OF GLYCYL GLYCINE, GLYCYL LEUCINE, GLYCYL ALANINE, GLYCYL ASPARAGINE, GLYCYL ASPARTIC ACID, AND BIURET BASE BY EREPSIN

Content Provider	Scilit
Author	Northrop, John H. Simms, Henry S.
Copyright Year	1928
Description	1. The rate of hydrolysis at different pH values of glycyl glycine, glycyl leucine, glycyl alanine, glycyl asparagine, glycyl aspartic acid and biuret base has been determined. 2. The pH-activity curves obtained in this way differ for the different substrates. 3. The curves can be satisfactorily predicted by the assumption that erepsin is a weak acid or base with a dissociation constant of $10^{–7.6}$ and that the reaction takes place between a particular ionic species of the enzyme and of the substrate. There are several possible arrangements which will predict the experimental results. 4. The rate of inactivation of erepsin at various pH values has been determined and found to agree with the assumption used above, that the enzyme is a weak acid or base with a dissociation constant of about $10^{–7.6}$. 5. It is pointed out that if the mechanism assumed is correct, the determination of a significant value for the relative rate of hydrolysis of various peptides is a very uncertain procedure.
Related Links	http://jgp.rupress.org/content/12/2/313.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323707/pdf https://rupress.org/jgp/article-pdf/12/2/313/572826/313.pdf
Ending Page	328
Page Count	16
Starting Page	313
DOI	10.1085/jgp.12.2.313
Journal	The Journal of general physiology
Issue Number	2
Volume Number	12
Language	English
Publisher	Rockefeller University Press
Publisher Date	1928-11-20
Access Restriction	Open
Subject Keyword	Glycyl Glycine Alanine Curves Aspartic Leucine Asparagine Biuret Rate of Hydrolysis Journal: The Journal of general physiology (Vol- 12, Issue- 2)
Content Type	Text

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