NDLI: Type I Interferons (IFNs) Regulate Tumor Necrosis Factor–related Apoptosis-inducing Ligand (TRAIL) Expression on Human T Cells: A Novel Mechanism for the Antitumor Effects of Type I IFNs

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Type I Interferons (IFNs) Regulate Tumor Necrosis Factor–related Apoptosis-inducing Ligand (TRAIL) Expression on Human T Cells: A Novel Mechanism for the Antitumor Effects of Type I IFNs

Content Provider	Scilit
Author	Kayagaki, Nobuhiko Yamaguchi, Noriko Nakayama, Masafumi Eto, Hiroshi Okumura, Ko Yagita, Hideo
Copyright Year	1999
Description	Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a proapoptotic member of the TNF family of type II membrane proteins, which constitutes one component of T cell cytotoxicity. In this study, we investigated the expression and function of TRAIL in human peripheral blood T (PBT) cells. Although freshly isolated PBT cells did not express a detectable level of TRAIL on their surface, a remarkable TRAIL expression was rapidly induced on the surface of both CD4+ and CD8+ PBT cells upon stimulation with anti-CD3 monoclonal antibody and type I interferons (IFNs). This enhancement of TRAIL expression was a unique feature of type I IFNs (IFN-α and IFN-β), and neither type II IFN (IFN-γ) nor various other cytokines enhanced TRAIL expression on anti-CD3–stimulated PBT cells. Type I IFNs have been used for clinical treatment of renal cell carcinomas (RCCs), and we found that most RCC cell lines were susceptible to TRAIL-induced apoptosis. Type I IFNs substantially augmented cytotoxic activity of anti-CD3–stimulated PBT cells against RCC cell lines in a TRAIL-dependent manner. These results indicate a unique feature of type I IFNs to regulate TRAIL-mediated T cell cytotoxicity, which may be involved in the antitumor effects of type I IFNs against various tumors.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193058/pdf http://jem.rupress.org/content/jem/189/9/1451.full.pdf
Ending Page	1460
Page Count	10
Starting Page	1451
DOI	10.1084/jem.189.9.1451
Journal	The Journal of experimental medicine
Issue Number	9
Volume Number	189
Language	English
Publisher	Rockefeller University Press
Publisher Date	1999-05-03
Access Restriction	Open
Subject Keyword	Immunology Cytotoxic T Lymphocyte Cytotoxicity Trail Type I Interferon Renal Cell Carcinoma Journal: The Journal of experimental medicine (Vol- 189, Issue- 9)
Content Type	Text

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