NDLI: Baff Binds to the Tumor Necrosis Factor Receptor–Like Molecule B Cell Maturation Antigen and Is Important for Maintaining the Peripheral B Cell Population

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Baff Binds to the Tumor Necrosis Factor Receptor–Like Molecule B Cell Maturation Antigen and Is Important for Maintaining the Peripheral B Cell Population

Content Provider	Scilit
Author	Thompson, Jeffrey S. Schneider, Pascal Kalled, Susan L. Wang, Lichun Lefevre, Eric A. Cachero, Teresa G. Mackay, Fabienne Bixler, Sarah A. Zafari, Mohammad Liu, Zhong-Ying Woodcock, Stephen A. Qian, Fang Batten, Marcel Madry, Christine Richard, Yolande Benjamin, Christopher D. Browning, Jeffrey Tsapis, Andreas Tschopp, Jurg Ambrose, Christine
Copyright Year	2000
Description	Journal: The Journal of experimental medicine The tumor necrosis factor (TNF) family member B cell activating factor (BAFF) binds B cells and enhances B cell receptor–triggered proliferation. We find that B cell maturation antigen (BCMA), a predicted member of the TNF receptor family expressed primarily in mature B cells, is a receptor for BAFF. Although BCMA was previously localized to the Golgi apparatus, BCMA was found to be expressed on the surface of transfected cells and tonsillar B cells. A soluble form of BCMA, which inhibited the binding of BAFF to a B cell line, induced a dramatic decrease in the number of peripheral B cells when administered in vivo. Moreover, culturing splenic cells in the presence of BAFF increased survival of a percentage of the B cells. These results are consistent with a role for BAFF in maintaining homeostasis of the B cell population.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887706/pdf https://rupress.org/jem/article-pdf/192/1/129/979109/000648.pdf
ISSN	00221295
DOI	10.1084/jem.192.1.129
Journal	The Journal of experimental medicine
Issue Number	1
Volume Number	192
Language	English
Publisher	Rockefeller University Press
Publisher Date	2000-07-03
Access Restriction	Open
Subject Keyword	Journal: The Journal of experimental medicine Tumor Necrosis Factor B Lymphocyte Cell Survival
Content Type	Text
Resource Type	Article
Subject	Physiology

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