NDLI: Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells

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Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells

Content Provider	Scilit
Author	Blasius, Amanda L. Barchet, Winfried Cella, Marina Colonna, Marco
Copyright Year	2007
Description	Lymphoid organs contain a B220+CD11c+NK1.1+ cell population that was recently characterized as a novel dendritic cell (DC) subset that functionally overlaps with natural killer (NK) cells and plasmacytoid DCs (PDCs). Using Siglec-H and NK1.1 markers, we unambiguously dissected B220+CD11c+ cells and found that PDCs are the only professional interferon (IFN)-α–producing cells within this heterogeneous population. In contrast, B220+CD11c+NK1.1+ cells are a discrete NK cell subset capable of producing higher levels of IFN-γ than conventional NK cells. Unlike DCs, only a minute fraction of B220+CD11c+NK1.1+ cells in the spleen expressed major histocompatibility complex class II ex vivo or after stimulation with CpG. Consistent with being a NK cell subset, B220+CD11c+NK1.1+ cells depended primarily on interleukin 15 and common cytokine receptor γ chain signaling for their development. In terms of function, expression of distinctive cell surface receptors, and location in lymphoid organs, NK1.1+B220+CD11c+ appear to be the murine equivalent of human CD56bright NK cells.
Related Links	http://jem.rupress.org/content/204/11/2561.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118497/pdf
Ending Page	2568
Page Count	8
Starting Page	2561
DOI	10.1084/jem.20070991
Journal	The Journal of experimental medicine
Issue Number	11
Volume Number	204
Language	English
Publisher	Rockefeller University Press
Publisher Date	2007-10-29
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Function Ifn Nk Cells Cd11c B220 Pdcs Nk1.1 Nk Cell Subset Journal: The Journal of experimental medicine (Vol- 204, Issue- 11)
Content Type	Text

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