NDLI: Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling

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Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling

Content Provider	Scilit
Author	Platta, Harald W. Magraoui, Fouzi El Schlee, Daniel Grunau, Silke Girzalsky, Wolfgang Erdmann, Ralf
Copyright Year	2007
Description	Pex5p, which is the import receptor for peroxisomal matrix proteins harboring a type I signal sequence (PTS1), is mono- and polyubiquitinated in Saccharomyces cerevisiae. We identified Pex5p as a molecular target for Pex4p-dependent monoubiquitination and demonstrated that either poly- or monoubiquitination of the receptor is required for the ATP-dependent release of the protein from the peroxisomal membrane to the cytosol as part of the receptor cycle. Therefore, the energy requirement of the peroxisomal import pathway has to be extended by a second ATP-dependent step, namely receptor monoubiquitination.
Related Links	http://jcb.rupress.org/content/177/2/197.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064128/pdf
Ending Page	204
Page Count	8
Starting Page	197
DOI	10.1083/jcb.200611012
Journal	Journal of Cell Biology
Issue Number	2
Volume Number	177
Language	English
Publisher	Rockefeller University Press
Publisher Date	2007-04-23
Access Restriction	Open
Subject Keyword	Cell Biology Proteins Pex5p Peroxisomal Import Polyubiquitinated Pts1 Saccharomyces Pex4p Matrix Recycling Journal: Journal of Cell Biology (Vol- 177, Issue- 2)
Content Type	Text

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