NDLI: One naive T cell, multiple fates in CD8+ T cell differentiation

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One naive T cell, multiple fates in CD8+ T cell differentiation

Content Provider	Scilit
Author	Gerlach, Carmen Heijst, Jeroen W. J. Van Swart, Erwin Sie, Daoud Armstrong, Nicola Kerkhoven, Ron M. Zehn, Dietmar Bevan, Michael J. Schepers, Koen Schumacher, Ton N. M.
Copyright Year	2010
Description	The mechanism by which the immune system produces effector and memory T cells is largely unclear. To allow a large-scale assessment of the development of single naive T cells into different subsets, we have developed a technology that introduces unique genetic tags (barcodes) into naive T cells. By comparing the barcodes present in antigen-specific effector and memory T cell populations in systemic and local infection models, at different anatomical sites, and for TCR–pMHC interactions of different avidities, we demonstrate that under all conditions tested, individual naive T cells yield both effector and memory CD8+ T cell progeny. This indicates that effector and memory fate decisions are not determined by the nature of the priming antigen-presenting cell or the time of T cell priming. Instead, for both low and high avidity T cells, individual naive T cells have multiple fates and can differentiate into effector and memory T cell subsets.
Related Links	http://jem.rupress.org/content/207/6/1235.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882844/pdf
Ending Page	1246
Page Count	12
Starting Page	1235
DOI	10.1084/jem.20091175
Journal	The Journal of experimental medicine
Issue Number	6
Volume Number	207
Language	English
Publisher	Rockefeller University Press
Publisher Date	2010-05-17
Access Restriction	Open
Subject Keyword	Immunology Research and Experimental Medicine Differentiation Priming Antigen Memory T Cell Barcodes Naive T Cells Effector and Memory Fates Journal: The Journal of experimental medicine (Vol- 207, Issue- 6)
Content Type	Text

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