NDLI: Na+ and K+ transport at basolateral membranes of epithelial cells. III. Voltage independence of basolateral membrane Na+ efflux.

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Na+ and K+ transport at basolateral membranes of epithelial cells. III. Voltage independence of basolateral membrane Na+ efflux.

Content Provider	Scilit
Author	Cox, T. C. Helman, S. I.
Copyright Year	1986
Description	Journal: The Journal of general physiology Na+ efflux across basolateral membranes of isolated epithelia of frog skin was tested for voltage sensitivity. The intracellular Na+ transport pool was loaded with 24Na from the apical solution and the rate of isotope appearance in the basolateral solution (JNa23) was measured at timed intervals of 30 s. Basolateral membrane voltage was depolarized by either 50 mM K+, 5 mM Ba++, or 80 mM NH+4. Whereas within 30 s ouabain caused inhibition of JNa23, depolarization of Vb by 30-60 mV caused no significant change of JNa23. Thus, both pump-mediated and leak Na+ effluxes were voltage independent. Although the pumps are electrogenic, pump-mediated Na+ efflux is voltage independent, perhaps because of a nonlinear relationship between pump current and transmembrane voltage. Voltage independence of the leak Na+ efflux confirms a previous suggestion (Cox and Helman, 1983. American Journal of Physiology. 245:F312-F321) that basolateral membrane Na+ leak fluxes are electroneutral.
Related Links	http://jgp.rupress.org/content/87/3/503.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217612/pdf
ISSN	00221295
DOI	10.1085/jgp.87.3.503
Journal	The Journal of general physiology
Issue Number	3
Volume Number	87
Language	English
Publisher	Rockefeller University Press
Publisher Date	1986-03-01
Access Restriction	Open
Subject Keyword	Journal: The Journal of general physiology Basolateral Membranes Voltage Independent
Content Type	Text
Resource Type	Article
Subject	Physiology

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