NDLI: Dendritic cells are potent antigen-presenting cells for microbial superantigens.

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Dendritic cells are potent antigen-presenting cells for microbial superantigens.

Content Provider	Scilit
Author	Bhardwaj, N. Friedman, S. M. Cole, B. C. Nisanian, A. J.
Copyright Year	1992
Description	Dendritic cells are a small subset of human blood mononuclear cells that are potent stimulators of several T cell functions. Here we show they are 10-50-fold more potent than monocytes or B cells in inducing T cell responses to a panel of superantigens. Furthermore, dendritic cells can present femtomolar concentrations of superantigen to T cells even at numbers where other antigen-presenting cells (APCs) are inactive. Although dendritic cells express very high levels of the major histocompatibility complex products that are required to present superantigens, it is only necessary to pulse these APCs for 1 hour with picomolar levels of one superantigen, staphylococcal enterotoxin B, to maximally activate T cells. Our results suggest that very small amounts of superantigen will be immunogenic in vivo if presented on dendritic cells.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119099/pdf http://jem.rupress.org/content/175/1/267.full.pdf
Ending Page	273
Page Count	7
Starting Page	267
DOI	10.1084/jem.175.1.267
Journal	The Journal of experimental medicine
Issue Number	1
Volume Number	175
Language	English
Publisher	Rockefeller University Press
Publisher Date	1992-01-01
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Dendritic Cells Functions Apcs Superantigens Antigen Presenting Inducing T Cell Cells Are Potent Journal: The Journal of experimental medicine (Vol- 175, Issue- 1)
Content Type	Text

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