NDLI: Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow

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Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow

Content Provider	Scilit
Author	Shelef, Miriam Lin, Kuo-I Savitsky, David Liao, Jerry Calame, Kathryn
Copyright Year	2005
Description	Long-lived plasma cells, residing primarily in the bone marrow, continuously secrete antibody and provide an important component of humoral memory. However, when such cells secrete autoantibodies or become transformed, they can be pathogenic. We have shown recently that the transcriptional repressor B lymphocyte–induced maturation protein 1 (Blimp-1) is required for the formation of plasma cells. To determine what role Blimp-1 might play in maintenance of plasma cells, we generated mice in which the gene encoding Blimp-1 could be deleted in an inducible manner. Deletion of Blimp-1 either in vitro or in vivo leads to loss of previously formed B220LOCD138HI plasma cells. Using BrdU incorporation, we confirmed that Blimp-1 is required for the maintenance of nondividing, long-lived plasma cells in the bone marrow. Blimp-1 is also required for long-term maintenance of antigen-specific immunoglobulin in serum. Thus Blimp-1 is required not only for the formation but also for the maintenance of long-lived plasma cells. This finding provides the possibility of new drug design strategies for autoimmunity and multiple myeloma focused on blocking Blimp-1 expression or activity.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213334/pdf http://jem.rupress.org/content/202/11/1471.full.pdf
Ending Page	1476
Page Count	6
Starting Page	1471
DOI	10.1084/jem.20051611
Journal	The Journal of experimental medicine
Issue Number	11
Volume Number	202
Language	English
Publisher	Rockefeller University Press
Publisher Date	2005-11-28
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Antibody Multiple Myeloma Bone Marrow Antigen Maintenance Lived Plasma Cells Long Lived Plasma Journal: The Journal of experimental medicine (Vol- 202, Issue- 11)
Content Type	Text

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