NDLI: Interleukin 4–Producing Cd4 T Cells Arise from Different Precursors Depending on the Conditions of Antigen Exposure in Vivo

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Interleukin 4–Producing Cd4 T Cells Arise from Different Precursors Depending on the Conditions of Antigen Exposure in Vivo

Content Provider	Scilit
Author	Foucras, Gilles Gapin, Laurent Coureau, Christiane Kanellopoulos, Jean M. Guéry, Jean-Charles
Copyright Year	2000
Description	Journal: The Journal of experimental medicine The precursor origin of T helper (Th) cell subsets in vivo has been difficult to study and remains poorly investigated. We have previously shown that chronic administration of soluble protein antigen induces selective development of antigen-specific CD4 Th2 cells in genetically predisposed mouse strains. To analyze the origin of effector T cells in this model, we designed a competitive polymerase chain reaction–based approach to track public BV-J rearrangement expressed by CD4 T cells specific for hen egg white lysozyme (HEL) in BALB/c mice. We show that public T cell clones are predominantly associated with type 1 or 2 effector Th cells recovered after primary immunization in complete or incomplete Freund's adjuvant, respectively. Conversely, continuous administration of soluble antigen, which induces strong memory Th2 response, is associated with a dose-dependent reduction of public clone size by a mechanism resembling clonal anergy. Thus, soluble HEL–induced Th2 cells do not express the public complementarity determining region 3 motifs characteristic of immunogenic challenge in the presence of adjuvant. These results demonstrate that there are multiple pathways of induction of Th2 responses depending on the condition of antigen exposure in vivo, i.e., clonal immune deviation versus recruitment of a different pool of precursor cells.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195842/pdf http://jem.rupress.org/content/jem/191/4/683.full.pdf
ISSN	00221295
DOI	10.1084/jem.191.4.683
Journal	The Journal of experimental medicine
Issue Number	4
Volume Number	191
Language	English
Publisher	Rockefeller University Press
Publisher Date	2000-02-21
Access Restriction	Open
Subject Keyword	Journal: The Journal of experimental medicine Clonal Expansion Antigen-specific Public Repertoire Cd4 T Cell Subsets Chronic Antigen Stimulation Clonal Anergy
Content Type	Text
Resource Type	Article
Subject	Physiology

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