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Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10.
| Content Provider | Scilit |
|---|---|
| Author | Roth, I. Corry, D. B. Locksley, R. M. Abrams, J. S. Litton, M. J. Fisher, S. J. |
| Copyright Year | 1996 |
| Description | The mechanism by which the mammalian mother accepts the implanting fetus as an allograft remains unexplained, but is likely to be the result of a combination of factors. Mononuclear cytotrophoblasts, the specialized fetal cells of the placenta that invade the uterus, play an important role. These cells express HLA-G, an unusual major histocompatibility complex class I-B molecule, and secrete cytokines and pregnancy-specific proteins that can regulate immune function. We investigated whether cytotrophoblasts secrete interleukin 10 (IL-10), a cytokine that potently inhibits alloresponses in mixed lymphocyte reactions. Cytotrophoblasts from all stages of pregnancy produced IL-10 in vitro, but neither placental fibroblasts nor choriocarcinoma (malignant trophoblast) cell lines did so. Spontaneous IL-10 production averaged 650, 853, and 992 pg/10(6) cells in the first, second, and third trimesters of pregnancy, respectively. IL-10 secretion dropped approximately 10-fold after the first 24 h of culture, and was paralleled by a decrease in messenger RNA. IL-10 messenger RNA was detected in biopsies of the placenta and the portion of the uterus that contains invasive cytotrophoblasts, suggesting that this cytokine is also produced in vivo. IL-10 secreted by cytotrophoblasts in vitro is bioactive, as determined by its ability to suppress interferon gamma production in an allogeneic mixed lymphocyte reaction. We conclude that human cytotrophoblast IL-10 may be an important factor that contributes to maternal tolerance of the allogeneic fetus. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192727/pdf http://jem.rupress.org/content/184/2/539.full.pdf |
| Ending Page | 548 |
| Page Count | 10 |
| Starting Page | 539 |
| DOI | 10.1084/jem.184.2.539 |
| Journal | The Journal of experimental medicine |
| Issue Number | 2 |
| Volume Number | 184 |
| Language | English |
| Publisher | Rockefeller University Press |
| Publisher Date | 1996-08-01 |
| Access Restriction | Open |
| Subject Keyword | Reproductive Biology Function Pregnancy Proteins Placenta Tolerance Allogeneic Messenger Mixed Cytotrophoblasts Secrete Journal: The Journal of experimental medicine (Vol- 184, Issue- 2) |
| Content Type | Text |
