NDLI: Catha edulis Forsk. (Khat): Evaluation of its antidepressant-like Activity

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Catha edulis Forsk. (Khat): Evaluation of its antidepressant-like Activity

Content Provider	Scilit
Author	Alfaifi, Hassan Mohan, Syam Shaala, Lamiaa A. Alsanosy, Rashad Abdelwahab, Siddig Ibrahim Taha, Manal Mohamed Elhassan Syame, Sohier M.
Copyright Year	2017
Abstract	Background: Catha edulis Forsk. (Khat) is traditionally used for treating various disorders. Nevertheless there are no reports of any scientific assessment of its psychopharmacological properties. Objective: Therefore, the current study was designed to evaluate the antidepressant-like activity of Khat ethanolic extract using established animal models of depression and stress. Materials and Methods: Ninety healthy male albino mice were used in this study. Forced swim, tail suspension and head poking tests were utilized to evaluate the antidepressant-like activity of the ethanolic extract of Khat (100, 200 and 400 mg/kg, i.p.) and escitalopram (standard drug) which were administered 30 min prior to the tests. Phytochemical analysis of the standardized extract was conducted using liquid chromatography-mass spectroscopy (LC-MS). Results: A significant decrease in the head-dipping behavior was noticed after administration of 100, 200 and 400 mg/kg of Khat extract. Moreover, the extract significantly decreased the immobility time in tail suspension and forced swim tests. The presence of cathinone and cathine were detected in the extract using LC-MS. Conclusion: The current results suggest that the extract of Khat leaves has acute antidepressant properties and may have sedative effects. Abbreviations used: LC-MS: Liquid chromatography-mass spectroscopy; NIST: National institute of standard technology; SSRI: Serotonin reuptake inhibitors; FST: Forced swim test; TST: Tail suspension test.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538179/pdf
File Format	XHTML
ISSN	09731296
e-ISSN	09764062
DOI	10.4103/pm.pm_442_16
Journal	Pharmacognosy Magazine
Issue Number	50
Volume Number	13
Language	English
Publisher	Medknow
Access Restriction	Open
Subject Keyword	Integrative and Complementary Medicine Animal Models Antidepressant-like Activity Catha Edulis Depression Pharmacognosy Magazine, Volume 13, Issue 50
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmaceutical Science

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