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Study of the effect of oral gabapentin used as preemptive analgesia to attenuate post-operative pain in patients undergoing abdominal surgery under general anesthesia
| Content Provider | Scilit |
|---|---|
| Author | Parikh, Harshel G. Dash, Sananta Kumar Upasani, Chitra B. |
| Copyright Year | 2010 |
| Abstract | Aims: To study the effect of oral gabapentin used as preemptive analgesia to attenuate post operative pain in patients undergoing abdominal surgery under general anesthesia. Materials and Methods: In a randomized double blind study, 60 patients were divided into two groups. Group A received 600mg gabapentin and group B oral received placebo 1 h prior to surgery. Anesthesia was induced with Propofol 2 mg/kg and Vecuronium 0.1mg/kg and maintained with 60% N$ _{2}$ O in O$ _{2}$ and Vecuronium 0.02 mg/kg. All cases were given Fentanyl 2μg/kg as pre-medication and a repeat dose 1μg/kg at the end of the first hour. Assessment of post-operative pain was made with the visual analog score (VAS) at extubation (0 h), 2, 4, 6, 12, and 24 h post-operatively. Post-operative analgesia was provided with intravenous Tramadol. The first dose was given in the Post Anesthesia Care Unit as 2mg/kg, and repeated at 8 and 16 h. Rescue analgesia was given with Diclofenac 1.5mg/kg, slow intravenous. The number of doses of rescue analgesia in both the groups was noted. Results: The VAS scores at 0, 2, 4, 6, 12, and 24 h were 1.9 vs. 2.4 (P=0.002), 2.3 vs. 3.0 (P=0.000), 3.2 vs. 3.7 (P=0.006), 2.9 vs. 4.4 (P=0.000), 3.6 vs. 4.6 (P=0.000), and 3.7 vs.4.6 (P=0.000), respectively. Numbers of patients requiring rescue analgesia with Diclofenac were 3 vs. 14 (P=0.004). Conclusion: A single oral dose of gabapentin given pre-operatively enhanced the analgesic effect of Tramadol as it also reduced the requirement of rescue analgesia with Diclofenac. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980657/pdf http://www.saudija.org/article.asp?issn=1658-354X;year=2010;volume=4;issue=3;spage=137;epage=141;aulast=Parikh;type=2 |
| File Format | XHTML |
| ISSN | 1658354X |
| e-ISSN | 09753125 |
| DOI | 10.4103/1658-354x.71409 |
| Journal | Saudi Journal of Anaesthesia |
| Issue Number | 3 |
| Volume Number | 4 |
| Language | English |
| Publisher | Medknow |
| Access Restriction | Open |
| Subject Keyword | Anesthesiology Abdominal Surgery Gabapentin Pre-emptive Analgesia Post-operative Pain Saudi Journal of Anaesthesia, Volume 4, Issue 3 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Anesthesiology and Pain Medicine |
